CAHRA Workshop 2026

The CAHRA Review Workshop will host talks and discussion about "The Community-Wide Assessment of Cryo-EM Heterogeneous Reconstruction Algorithms (CAHRA) Challenge" and the wider subject of interpreting and reconstructing the heterogeneity present in cryo-EM datasets. This will include talks:

• setting out the ground-truth behind each challenge dataset and analysing their entries.
• from challenge winners/participants on their methodology
• from experts addressing a range of topics, such as current limitations, potential opportunities from the use of HRAs, examples of their use in studies of cryo-EM datasets and integrative approaches 

Talks at the workshop will be held in a hybrid manner, although please note that some speakers may request their presentation to be covered by a  "No Publication Policy" similar to that used at the Gordon Research Conference - these talks will not be broadcast or recorded.

There will be ample time for in-person participants to discuss scoring metrics and challenge results, identify shortcomings of existing methods, brainstorm future metrics, explore integrative techniques and to discuss optimal representation, deposition and reuse of heterogeneous structures.

The Workshop will be held in Diamond House at the Rutherford Appleton Laboratory (RAL), Harwell in Oxfordshire, UK on Thursday 17^th September and Friday 18^th September 2026. For in-person delegates, a limited numbers of rooms (free of charge, covered by DRIIMB sponsorship) are available at the Milton Hill House Hotel (MHH) on the nights of Wednesday 16th September and Thursday 17th September. This accommodation includes evening meals, breakfast and coach transport between RAL and MHH. These rooms will be allocated on a first-come, first-served basis upon registration. Lunch and coffee will be provided at RAL.

Confirmed speakers include:

• Peijun Zhang (University of Oxford)
• Sjors Scheres (MRC-LMB)
• Mingxu Hu (Shenzhen Academy of Research and Translation)
• David Haselbach (Research Institute of Molecular Pathology) [EMBO Young Investigator Network talk]
• Hamish Todd (Altos Labs)
• Stephanie Wankowicz (Wankowicz Lab)
• Kyle Morris (EBI)
• Others TBA!

ETAs and Visas:

If you do not have a UK or Irish passport, please double check whether you require a ETA or Visa. Please contact CCPEMEvents@stfc.ac.uk if you require a Visa supporting letter.

Parking at RAL:

If you will be driving to/from the workshop, and not using the coach from Milton Hill House, please let us know so we can reserve parking spaces on campus.