Xevo MRT P10 Mass Spectrometer

Backed by Science. Trusted by
Experts. Powered by MRT

Experience exceptional sensitivity at unprecedented acquisition speeds with the Xevo^TM MRT P10 Mass Spectrometer (MS), built on revolutionary multi-reflecting time-of-flight (MRT) technology, to expand analytical flexibility for the most demanding MS applications. 

Xevo CDMS

See what no one has seen before

With the breakthrough Xevo CDMS instrument, you can achieve precise measurement of challenging large and highly heterogeneous molecules, including viral vectors, virus-like particles (VLPs), RNA, and protein complexes, that were previously out of reach for mass characterization.

Cyclic IMS P20 Mass Spectrometer

Insight revealed, not inferred

Whether advancing discovery in academia or innovation in industry, the next generation Cyclic^TM IMS P20 Mass Spectrometer delivers clearer, more confident interpretation of complex biology. By combining high‑resolution cyclic ion mobility with precise mass analysis it separates co‑eluting and isomeric species, simplifying complex ion populations and enabling more interpretable data. 

Xevo TQ Absolute XR Mass Spectrometer

Quantitate with Absolute power and eXtreme robustness

Gain absolute confidence to make powerful decisions and reach lower limits of quantitation, maintaining optimum sensitivity for longer, with the Xevo TQ Absolute XR Mass Spectrometer instrument.

Monday, August 24th – 12:45 – 1:45

Seminar title: Beyond Structure - Unlocking Biological Heterogeneity with Native Mass Spectrometry
Location - Salon Tête d'Or

Discover how native MS, HDX-MS, and CDMS reveal molecular complexity that other approaches miss, and how advanced structural MS workflows are accelerating biopharmaceutical characterization. We will also explore emerging trends in structural biology and therapeutic development.

Agenda

Welcome & Introduction
David Ballantyne, Waters Corporation

Tackling the Heterogeneity Challenge in Structural Biology with Native Mass Spectrometry
Mowei Zhou, Zhejiang University

From Structural Insight to Industrial Impact: Applying Native MS, HDX-MS, and CDMS in Biopharmaceutical Characterization
Esther Martin, AstraZeneca

Q&A

Wednesday, August 26th - 12:45 pm - 1:45 pm

Seminar title:  Advances in HRMS; Addressing the Challenges in Omics, Structural and Spatial Biology
Location - Salon Tête d'Or

Explore how recent advances in multi-reflecting time-of-flight (MRT) mass analysers are expanding the analytical possibilities of high-resolution mass spectrometry (HRMS).

Aligned with the conference, this session will show how the Xevo MRT P10 Mass Spectrometer combines high resolving power, sub-ppm mass accuracy, fast spectral acquisition rates, sensitivity, and long-term stability to support confident molecular characterization in complex biological systems.

From examples spanning integrated multi-omics, spatial biology, and structural biology, the seminar will highlight how next-generation HRMS performance can help turn increasingly complex samples into clearer, more actionable biological insight. The session will also look beyond classical omics applications to hydrogen-deuterium exchange mass spectrometry (HDX-MS), demonstrating how both an ion mobility mass spectrometer as well as the Xevo MRT P10 MS can probe protein folding, protein-protein interactions, and protein dynamics.

Agenda

Welcome and Introduction
Dr. James Langridge, Waters Corporation

Advances in HRMS: Addressing Challenges in Omics and Structural and Spatial Biology
Dr. Christopher Titman, Waters Corporation

Probing Protein Structure, Dynamics, and Interactions Using HDX-MS
Dr. Romain Malempre, University of Oxford 

Q&A

Check out Waters Posters at IMSC

Evaluation of Wideband Enhancement and DIA methods for improved sensitivity/specificity in MSI applications using SELECT SERIES™ Cyclic IMS

Presenter: Emmanuelle Claude 

Boosting sensitivity in peptide-level studies; Cyclic IMS-enabled Wideband Enhancement of CID and ECD product ions

Presenter: Tommaso Miraval 

End-to-End High-Throughput Biotransformation Workflow: Automated Data Acquisition and Processing of Sub-Second UHPLC Peaks Using Multi-Reflecting Time-of-Flight Mass Spectrometry and Dedicated Data-Mining Tools

Presenter: Rachel Sanig 

Identification of Novel Per-and-polyfluoroalkyl substance (PFAS) Isoform in Textile Using a Multi-Reflecting Time-of-Flight Mass Spectrometer Technology

Presenter: Rachel Sanig 

Characterizing lipid nanoparticle vaccines using CDMS and FFF-MALS: A multi-dimensional approach

Presenter: David Ballantyne

Enabling deep proteome coverage at ultra-high throughput using stepped quadrupole DIA on a novel MRT benchtop MS

Presenter: Ashley Sage 

Increasing throughput in collision-induced unfolding studies: Enhancing sensitivity and streamlining set-up

Presenter: Tommaso Miraval

Resolving Disease‑Linked Plasma Glycoforms Using High‑Accuracy Multi-Reflecting Time-of-Flight Mass Spectrometry in Bipolar Disorder and Schizophrenia Cohorts

Presenter: Ashley Sage

Automated ELIT-CDMS for AAV Analysis

Presenter: Emily Christofi

Addressing the challenge of rapid drug metabolite identification using Cyclic Ion Mobility Mass Spectrometry

Presenter: Freddy Droye

Multi-omics analyses of fecal extracts to explore the microbiome of rats following administration of an agonist for the
GPR40 receptor

Presenter: Christopher Titman 

Robust impurity profiling of therapeutic oligonucleotides using single‑quadrupole LC‑MS in a GMP quality control setting

Presenter: Cristian Cojocariu 

Evaluating the mobility-size-shape relationship of nanosized ions across size-pressure scales in Ion Mobility Spectrometry (IMS)

Presenter: Kacper Kulikowski 

Analytical Repeatability and Precision of the Xevo CDMS System for AAV Capsid Characterization

Presenter: Emily Christofi

DESI Imaging: small molecule metabolites on tissue using the Xevo Multi-Reflecting time-of-flight mass spectrometer

Presenter: Emmanuelle Claude 

Multi-modal Imaging: Utilizing High-Resolution DESI Followed by MALDI-ICH to Analyze Clear Cell Renal Cell Carcinoma Biopsies

Presenter: Greice Zickuhr

A prototype MALDI CYCLIC IMS QTof enables the ion mobility separation of lipid isomers

Presenter: Patricia Prabutzki

Integrated Ion Mobility and Collision Cross Section Determination of Precursor and Product Ions by Travelling Wave Cyclic Ion Mobility–Mass Spectrometry

Presenter: Guillaume Bois-Salvaro

Advanced Performance in small metabolite imaging in human breast and bladder cancer tissues using a Xevo MRT Mass Spectrometer

Presenter: Emmanuelle Claude 

Unmasking Biotherapeutic Heterogeneity: CDMS as a Next-Generation Tool for Viral, Vaccine, and Gene Delivery System Characterization

Presenter: David Ballantyne

High throughput multi-omic analyses at the single cell level using analytical scale chromatography with a multi-reflecting high resolution mass spectrometer

Presenter: Christopher Titman