In-depth Look into Softgel Formulation, Manufacturing and Troubleshooting

Softgels are widely popular dose forms for liquid that represent the most important oral form for less than 5 milliliters of liquid. Additionally, softgels are vital as a lipid delivery system, enhancing both solubility and permeation of Active Pharmaceutical Ingredients (APIs) by targeting the lipid absorption route. Softgels may appear to be a simple, two-part system; shell and fill. However, softgels are far more complex requiring both an understanding of the science behind the ingredient selection, formulation balance, and compatibility, while also requiring expertise in manufacturing, sealing, and drying to produce an acceptable finished product. In this 6-hour, fully accredited training, participants will identify the full scope of the softgel process. The first 3-hour session covers the manufacturing process and the resolution of defects. The second 3-hour session covers the ingredients, formulation, bench and pilot development phase of the softgel development/investigation process.