Agenda - Cholangiocarcinoma Foundation Annual Conference

7am | Registration & CCF Store Open

7am - 8am | Breakfast

8am - 8:30am | Opening Session

Presenter: Stacie Lindsey | Title: Welcome, Where We’ve Been and Where We Are Going

Presenter: Melinda Bachini | Title: Advocacy Updates

8:30am - 8:45am | Presenter: Lilian Chavira | Title: Rooted in FAITH, Driven by LOVE, Fueled by HOPE

SESSION CHAIRS | CCF Advocacy Team

8:45am - 9am | Presenter: Stephanie Moore | Title: Nutrition considerations for CFF patients and caregivers: Tips for eating well

9am - 9:15am | Presenter: Amelia Wagenknecht | Title: Movement Is Medicine: Exercising During & After Cholangiocarcinoma

9:15am - 9:30am | Presenter: Chelsie Silveira | Title: Coping with the Unknown

9:30am - 9:45am | Presenter: Sofia Fernandez | Title: Navigating Insurance and Finances

9:45am - 10am | Presenter: Moore, Wagenknecht, Silveira, and Fernandez | Title: Q&A

10am - 10:30am | Break/Networking

SESSION CHAIRS | CCF Advocacy Team

10:30am - 11am | Presenter: Midhun Malla | Title: Navigating Cholangiocarcinoma: Knowledge, Options and Hope

11am - 11:20am | Presenter: Shishir Maithel | Title: Surgery for Cholangiocarcinoma: One Part of the Treatment Journey

11:20am - 11:40am | Presenter: Mark Ghobrial | Title: Outcomes of Transplantation for Intrahepatic CCA

11:40am - 12pm | Presenter: Marina Baretti | Title: Clinical Trials in Cholangiocarcinoma: Myths, Facts, and Opportunities

12pm - 12:15pm | Presenter: Trudy Wu | Title: Does “Unresectable” Mean “Untreatable”? The Role of Local Radiation Therapy & Ask the Expert

12:15pm - 12:30pm | Presenter: Hop Sanderson Tran Cao | Title: Histotripsy - Facts, Fiction, and the Space in Between

12:30pm - 1:30pm | Lunch

1:30pm - 1:50pm | Presenter: Mandy Wallace | Title: Patient Perspective

SESSION CHAIRS | Luke Boulter & Haley Ellis

1:50pm - 2:20pm | Presenter: Nabeel Bardeesy | Title: Therapy Resistance and Combination Strategies in Cholangiocarcinoma: Navigating Adaptive Responses and Lineage States

SESSION CHAIRS | CCF Advocacy Team

2:30pm - 2:45pm | Presenter: Erin Linnenbringer | Title: Working Together: Insights from a Participant-Driven Cancer Genome Study”

2:45pm - 3pm | Presenter: Amerti Guta | Title: Updates and Emerging Insights from the Cholangiocarcinoma Genome-Wide Association Study(GWAS)

3pm - 3:30pm | Break/Networking

SESSION CHAIRS | CCF Advocacy Team

3:30pm - 4pm | Presenter: Eric Tran | Title: The evolving landscape of cellular immunotherapy in cholangiocarcinoma

4pm - 5pm | Presenter: Shishir Maithel, Haley Ellis, Trudy Wu | Topic: Ask the Expert

5pm | CCF Store Closed

5pm - 6:30pm | Dinner

7am | Registration & CCF Store Open

7am - 8am | Breakfast

8am - 8:30am | Opening Session

Presenter: Stacie Lindsey | Title: Welcome, Where We’ve Been and Where We Are Going

Presenter: Melinda Bachini | Title: Advocacy Updates

8:30am - 8:45am | Presenter: Lilian Chavira | Title: Rooted in FAITH, Driven by LOVE, Fueled by HOPE

8:45am - 8:50am | Transition to Ballroom I

SESSION CHAIRS | James Cleary & Justin Lo

8:50am - 9:10am | Presenter: Haeseong Park | Topic: Claudin 18.2 | Title: TBD

9:10am - 9:30am | Presenter: Edward Jarman | Title: Early neoplastic transition states as targets for cholangiocarcinoma prevention

9:30am - 9:35am | Co-Chair Introduction of Juniors

9:35am - 10am | Presenter: Junior Faculty | Title: Junior Speed Talks

9:35am - 9:39am | Presenter: Rory Smoot | Title: TEAD Inhibition by IAG933 as a Novel Therapeutic Strategy for Cholangiocarcinoma

9:39am – 9:43 am | Presenter: Vivian Ortiz | Title: IRAK4 Is a Potential Target for the Treatment of Biliary Tract Cancer

9:43am - 9:47am | Presenter: Alberto Tinahones-Ruano | Title: Functional and Mechanistic Role of lncRNA-A1 in Cholangiocarcinoma

9:47am - 9:51am | Presenter: Akhila Reddy | Title: Characterizing Genomic, Transcriptomic, and Clinical Landscape in CCNE/CCND Amplified Biliary Tract Cancer

9:51am - 9:55am | Presenter: Felix Beaudry | Title: Biliary Tract Cancer Consensus Molecular Subtypes Improve Outcome Stratification Over Anatomy

10am - 10:30am | Break/Networking

SESSION CHAIRS | Greg Lesinski & Ainhoa Lapitz

10:30am - 10:50am | Presenter: Guido Carpino | Title: Clinical and Molecular Relevance of Histo-Morphology in Cholangiocarcinoma: The European CCA Histology Registry Experience

10:50am - 11:10am | Presenter: Jesper Andersen | Title: DELPI-AI: Deploying artificial intelligence to improve biliary tract cancer management

11:10am - 11:30am | Presenter: Mitchell Ho | Title: Development of Mesothelin-Targeting CAR T Cell Therapy

11:30am - 11:50am | Presenter: Antonella Cammarota | Title: B-cell immunity in intrahepatic cholangiocarcinoma: from immune dysfunction to tertiary lymphoid structures

11:50am - 12:10pm | Presenter: Robert Schwabe | Title: Multimodal Combination Therapy for Cholangiocarcinoma

12:10pm - 12:15pm | Co-Chair Introduction of Juniors

12:15pm - 12:30pm | Presenter: Junior Faculty | Title: Junior Speed Talks

12:15pm - 12:20pm | Presenter: Rime Jebai | Title: Association Between Diabetes and Gallbladder Cancer Risk Among Chilean Women with Gallstones: Findings from the Chile Biliary Longitudinal Study

12:20pm - 12:25pm | Presenter: Alexandra Wolf | Title: A novel immuno-oncology preclinical pipeline to study FGFR2 fusion-driven cholangiocarcinoma

12:25pm - 12:30pm | Presenter: Mohamed Nuh | Title: Therapeutic Targeting of IDHl Mutations in Intrahepatic Cholangiocarcinoma Arising in Oilier Disease

12:30pm - 1:30pm | Lunch

1:30pm - 1:50pm | Presenter: Mandy Wallace | Title: Patient Perspective

SESSION CHAIRS | Luke Boulter & Haley Ellis

1:50pm - 2:20pm | Presenter: Nabeel Bardeesy | Title: Therapy Resistance and Combination Strategies in Cholangiocarcinoma: Navigating Adaptive Responses and Lineage States

2:20pm - 2:40pm | Presenter: Vindhya Vijay | Title: Beyond Oncogenes and Tumor Suppressors: Lineage Identity Defines Therapeutic Vulnerabilities in Cholangiocarcinoma

2:40pm - 3pm | Presenter: Matias Avila | Title: Protein Arginine Methyltransferases as Potential Pharmacological Targets in Cholangiocarcinoma

3pm - 3:30pm | Break/Networking

SESSION CHAIRS | Sita Kugel & Bridget Keenan

3:30pm - 3:50pm | Presenter: Jesús Bañales | Title: Aurkine: New Hope for Hard-to-Treat Solid Tumors

3:50pm - 4:10pm | Presenter: Tim Greten | Title: B cells mediate anti-tumor immunity upon combined immune checkpoint inhibitor plus anti-VEGF therapy

4:10pm - 4:30pm | Presenter: Daniela Sia | Title: B7-H4 drives stromal remodeling and CCA growth through T cell-independent mechanisms

4:30pm - 4:50pm | Presenter: Colm O'Rourke | Title: Rapid Progressors & Long Survivors: A Translational Perspective

4:50pm - 5:10pm | Presenter: Cassian Yee | Title: Uncommon Cancer, Common Insight: TCR Targets in Cholangiocarcinoma

5pm | CCF Store Closed

5:10pm - 6:30pm | Dinner

7am | CCF Store Open

7am - 8am | Breakfast

8am - 8:30am | Presenter: Juan Valle | Title: Advancing Cholangiocarcinoma Research Together

8:30am - 8:50am | Presenter: Steven West | Title: Patient Perspective

SESSION CHAIRS | Lewis Roberts & Soravis Osataphan

8:50am - 9:10am | Presenter: Adriana Gamboa | Title: Management of localized disease (to cover surgery, transplantation, locoregional)

9:10am - 9:30am | Presenter: Tim Pawlik | Title: On the Margin: Surgical Approaches to Borderline Intrahepatic Cholangiocarcinoma

9:30am - 9:50am | Presenter: Sheraz Yaqub | Title: Pushing the limits, expanding possibilities: surgery for cholangiocarcinoma

9:50am - 10am | General Discussion

10am - 10:30am | Break/Networking

SESSION CHAIRS | Ryan Fields & Mark Yarchoan

10:30am - 10:50am | Presenter: Govindarajan Narayanan | Topic: Y90 vs Heat | Title: TBD

10:50am - 11:10am | Presenter: Nilo Azad | Title: Cholangiocarcinoma gets an invitation to the KRAS ball

11:10am - 11:30am | Presenter: Lipika Goyal | Title: From Histology to Biology: How Basket Trials are Redefining Cholangiocarcinoma

11:30am - 11:50am | Presenter: Changhoon Yoo | Title: What Can We Learn from Trials in Asia

11:50am - 12:30pm | Presenter: Katie Kelley, Shishir Maithel, Eugene Koay, James Harding, Ryan Fields | Title: Multidisciplinary Tumor Board

12:30pm - 1:30pm | Lunch

1:30pm - 1:50pm | Presenter: Michelle Lundy | Title: Caregiver Perspective

SESSION CHAIRS | Sameek Roychowdhury & Farinaz Barghi

1:50pm - 2:10pm | Presenter: Anthony El-Khoueiry | Topic: Looking Down the Pipeline | Title: TBD

2:10pm - 2:30pm | Presenter: Funda Meric-Bernstam | Title: ADCs for biliary tract cancers

2:30pm - 2:50pm | Presenter: Mark Yarchoan | Title: Clinical Progress in Cholangiocarcinoma: Review of Key Industry Abstracts

2:50pm - 3pm | General Discussion

3pm - 3:30pm | Break/Networking

3:30pm - 5:30pm | Oral/Poster Walk & Fellowships Presentations

3pm- 3:40 | Poster Walk

Clinical Walk | Sheraz Yaqub, Jill Koshiol, George Riddle
Science Walk | Lara Heij, Luke Boulter, Art Brace

SESSION CHAIRS | Flavio Rocha and Rachna Shroff

3:45pm - 4:15pm | Poster Oral Presentations

3:45pm – 3:51pm | Presenter: Valerie Gunchick Title: Cholangiocarcinoma incidence in the United States: Analysis of 121,732,956 adult individuals

3:51pm – 3:57pm | Presenter: Enis Ozmert Title: Aptamer-targeted delivery of siRNA therapeutics for cholangiocarcinoma

3:57pm – 4:03pm | Presenter: Ainhoa Lapitz Title: Novel blood metabolomic tests for the diagnosis of Primary Sclerosing Cholangitis and associated Cholangiocarcinoma

4:03pm – 4:09pm | Presenter: Katie Kelley Title: A phase 1/2 trial investigating ivosidenib plus nivolumab and ipilimumab in patients with previously treated mIDH1 CCA

4:09pm – 4:15pm | Presenter: Kirk Fowers Title: Y90 Glass Microsphere Treatment for iCCA: Final Results from the Largest Prospective Real-World Study (PROACTIF)

4:15pm - 5:30pm | Fellowship Presentations

4:15pm – 4:21pm | Presenter: Ghada Nouairia Title: Developing a blood-based test for diagnosis, prognosis, and monitoring of cholangiocarcinoma

4:21pm – 4:27pm | Presenter: Dong-Gi Mun Title: Novel glycopeptide biomarkers for diagnosis of cholangiocarcinoma

4:27pm – 4:33pm | Presenter: Ainhoa Lapitz Title: Development of a polygenic risk score to predict recurrence and survival in patients with resected cholangiocarcinoma

4:33pm – 4:39pm | Presenter: Soravis Osataphan Title: Mapping the tumor and immune microenvironment in liver-fluke-associated cholangiocarcinoma

4:39pm – 4:45pm | Presenter: Binbin Li Title: Chemotherapy-Induced Senescence Promotes Tumor Immunosuppression in Cholangiocarcinoma

4:45pm – 4:51pm | Presenter: Justin Lo Title: Targeting Pin1 in cholangiocarcinoma tumor and stromal cells using siRNA therapeutics

4:51pm – 4:57pm | Presenter: Farinaz Barghi Title: Therapeutic Strategies for Targeting KRAS in Biliary Tract Carcinoma

4:57pm – 5:03pm | Presenter: Georgios Koulios Title: Inhibition of tropomyosin receptor kinase signaling as a therapeutic approach for intrahepatic cholangiocarcinoma

5:03pm – 5:09pm | Presenter: Davide Povero Title: BAP1 loss-of-function protects mitochondria and confers cholangiocarcinoma resistance to ferroptosis

5:09pm – 5:15pm | Presenter: Haley Ellis Title: Resistance to Mutant IDH1 Inhibition in Cholangiocarcinoma

5:30pm - 6pm | A Toast to the Future

6pm | CCF Store Closed

6pm - 9pm | Awards Ceremony & Dinner

7am | CCF Store Open

7am - 8am | Breakfast

8am - 8:20am | Presenter: Keaton Herzer | Title: Moving Faster Than CCA: Fighting the System & Cancer

SESSION CHAIRS | Tim Greten & Davide Povero

8:20am - 8:50am | Presenter: Tak Mak | Title: Beyond Immune Checkpoint Blockade: Emerging Strategies

8:50am - 9:10am | Presenter: Eugene Koay | Title: Multidisciplinary Tumor Board: Establishing evidence to use high dose radiotherapy for cholangiocarcinoma

9:10am - 9:30am | Presenter: Skye Mayo | Title: Hepatic Arterial Infusion Pump Chemotherapy for Intrahepatic Cholangiocarcinoma: Improving Survival and Quality of Life

9:30am - 9:50am | Presenter: Arndt Vogel | Title: Sequencing: when to intervene with IR and when not to

9:50am - 10am | General Discussion

10am - 10:30am | Break/Networking

SESSION CHAIRS | Juan Valle & Ghada Nouairia

10:30am - 11am | Presenter: Gregory Gores | Title: Research in Cholangiocarcinoma: Accomplishments, Advances and Aspirations

11am - 11:20am | Presenter: Milind Javle | Title: Artificial Intelligence vs. Clinical Experience: Who Will Lead the Future of Cholangiocarcinoma Care?

11:20am - 11:40am | Presenter: Stephen Rossi | Title: Bridging the PSC and CCA Patient Communities in Clinical Research: Moving the Patient Voice into Action

11:40am - 11:44am | Presenter: Luke Bolter & Tim Greten | Title: Conference Co-Chairs Closing Remarks

11:44am - 12:04pm | Presenter: Melinda Bachini, Juan Valle & Stacie Lindsey | Title: Closing Session

12pm | CCF Store Closed